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Figure S1: Activations induced by the auditory stimuli (vs. Rest) in two individuals (one saline treated bird and one DSP-4 treated bird). The statistical parametric maps (unilateral one sample t-test) are superimposed on anatomical images coming from the zebra finch atlas. They illustrate the bilateral activation of Field L, the equivalent of the mammalian primary auditory cortex, and the (caudally and frontally) adjacent secondary auditory regions.

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T values are color coded according to the scales displayed on the right side of the figure. Only voxels in which the t-test was found significant (p value. Download lagu mashumaro radwimps. Conclusions/Significance The level of norepinephrine throughout the telencephalon is known to be high in alert birds and low in sleeping birds.

Our results suggest that norepinephrine activity can be further decreased, giving rise to a strong own song selective signal in dorsal NCM. This latent own song selective signal, which is only revealed under conditions of very low noradrenergic activity, might play a role in the auditory feedback and/or the integration of this feedback with the motor circuitry for vocal learning and maintenance. Introduction The role of norepinephrine (NE) in the neurobiology of birdsong has recently been the focus of multiple studies but still remains poorly understood. Previous neuroanatomical and neurochemical studies have identified a dense noradrenergic innervation of the song control and auditory brain regions of songbirds –. The presence of high concentrations of NE and NE receptors in the song control and auditory nuclei, associated with the observation that the development of the noradrenergic innervation closely parallels song learning, have led to the hypothesis that NE might be involved in the control of song production, perception and learning (for a review, see ).

The songbird brain is able to discriminate between the bird's own song (BOS) and other conspecific (CON) songs –. Since song is a learned behavior, the development of BOS selectivity necessarily involves experience-dependent mechanisms, and brain regions sensitive to self-generated vocalizations could mediate the auditory feedback critical for song learning and song maintenance. Electrophysiological evidence indicates that NE can suppress BOS responsiveness in song control regions,. The main goal of the present study was to further investigate the role of NE on BOS selectivity. The selective noradrenergic neurotoxin DSP-4 causes substantial and long-lasting depletion of NE inputs in the mammalian and avian telencephalon that derive from the locus coeruleus and the nucleus subcoeruleus ventralis while leaving noradrenergic inputs to the hypothalamus originating from other noradrenergic cell groups relatively unaffected (see – for discussion). The mechanisms controlling this differential impact of the drug have not been identified to our knowledge.

Virtual Bouzouki is a library of samples of Greek stringed plucked musical instrument, bazooka, with realistic sound and lots of functions. Virtual Bouzouki contains all kinds of tremolo with the ability to change the speed, and the user can also switch the case for the Polyphonic and Monophonic modes. No sample libraries existed that truly captured this beautiful instrument in great depth and detail, until now! Our 8-string acoustic bouzouki has been thoroughly sampled and produced with all the love and care you would expect from a next-generation virtual instrument. Virtual bouzouki kontakt libraries online. Virtual Bouzouki & Rebetiko Instruments was created and produced by Stavros Genaridis, a Greek musician currently living in Sweden, who gave us the permission to sell this magnificent library via our website. You might have heard that Greece is all about sun, vacation, swimming, ouzo, beautiful islands and magnificent history. Akki Plugs releases Virtual Bouzouki. Jun 12, 2009. Akki Plugs has released Virtual Bouzouki, a sample library for Kontakt. Virtual Bouzouki is a Greek bouzouki sample library that with it’s realistic sound and it’s many functions will spread the Greek spirit around the world! Virtual Bouzouki is a Kontakt Player instrument based on. Virtual Bouzouki is a Greek bouzouki sample library that with it's realistic sound and it's many functions will spread the Greek spirit around the world! Virtual Bouzouki is a Kontakt Player instrument based on advanced script programming and has different playing styles and techniques which gives you a brilliant sound.

DSP-4 has been widely used to lower brain NE in order to investigate the functions of the central noradrenergic system in birds, –. Using functional Magnetic Resonance Imaging (fMRI), we assessed how DSP-4-induced noradrenergic denervation affects BOS selectivity in the telencephalic auditory and song control regions of anesthetized male zebra finches, namely Field L, NCM, CMM, CML, HVC, RA, LMAN and area X (see section for the meaning of the abbreviations). Effects of DSP-4 on BOS selectivity Three song stimuli were used in the fMRI experiment: the BOS, a familiar conspecific song (CON) and a heterospecific song (HET). BOS selectivity was assessed in each experimental group by comparing the neural activation induced by the perception of the BOS and the perception of the CON ([BOS minus CON]). Potential DSP-4 effects were measured by comparing BOS selectivity between the two experimental groups ([BOS minus CON] dsp-4 vs. [BOS minus CON] saline).

This analysis revealed a significant difference in a cluster located in the dorsal part of the left NCM extending to dorsal Field L (F max i.e. Voxel presenting the maximal F value among all significant voxels of the cluster = 13.02, p = 0.008) (). A similar non-significant trend was found in the right dorsal NCM/Field L region. The presence of this trend argues against a lateralization of the effect but does not allow excluding it. Post-hoc analyses of the significant cluster in left NCM/Field L indicated a significantly higher activation induced by BOS than by CON in the DSP-4 group (t max i.e. Voxel presenting the maximal t value among all significant voxels of the cluster = 3.52, p = 0.003). Spin-echo fMRI, as implemented in the present study, can detect statistically significant differential activations triggered by different stimuli at the group level but not at the individual level.

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